Optimal Control Strategy for Abnormal Innate Immune Response
نویسندگان
چکیده
منابع مشابه
Optimal Control Strategy for Abnormal Innate Immune Response
Innate immune response plays an important role in control and clearance of pathogens following viral infection. However, in the majority of virus-infected individuals, the response is insufficient because viruses are known to use different evasion strategies to escape immune response. In this study, we use optimal control theory to investigate how to control the innate immune response. We prese...
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Treatment of a pathogenic disease process is interpreted as the optimal control of a dynamic system. Evolution of the disease is characterized by a non-linear, fourth-order ordinary differential equation that describes concentrations of pathogens, plasma cells, and antibodies, as well as a numerical indication of patient health. Without control, the dynamic model evidences sub-clinical or clini...
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In this paper we consider a perturbed linear-quadratic control problem on a finite interval. The only difference from the traditional LQ-control problem is that the problem has an extra linear term in the cost function which makes it time-dependent. The major motivation for this extension comes from [4] where we consider applications of very efficient primal-dual interior-point algorithms to th...
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ژورنال
عنوان ژورنال: Computational and Mathematical Methods in Medicine
سال: 2015
ISSN: 1748-670X,1748-6718
DOI: 10.1155/2015/386235